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Abstract The authors report a case of purine nucleoside phosphorylase PNP deficiency for the first time from India. The case presented with bisexual escorts dayton severe infections, developmental delays, seizures and progressive neurological deterioration. The diagnosis of primary immunodeficiency disorder was delayed in spite of recurrent infection due to predominant neurological symptoms. Sequencing of the PNP gene revealed a novel mutation resulting in a premature stop codon.

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